反应 #422276

反应方程式

Iodomethane

6-(4-methylthiazol-2-ylamino)-5-phenoxypyridin-3-ol

potassium carbonate

→

title compound

N-(5-methoxy-3-phenoxypyridin-2-yl)-4-methylthiazol-2-amine

溶剂

DMF

反应条件

后处理

1. 1
   其他The reaction mixture is partitioned between water and ether
2. 2
   洗涤The organic layer is washed with water
3. 3
   其他dried
4. 4
   浓缩concentrated
5. 5
   其他The residue is purified by silica gel chromatography
6. 6
   洗涤eluting with 15-20% EtOAc in hexanes

实验过程

Iodomethane (0.0362 g, 0.255 mmol) is added to a mixture of 6-(4-methylthiazol-2-ylamino)-5-phenoxypyridin-3-ol (0.255 mmol) and potassium carbonate (0.0794 g, 0.574 mmol) in DMF (3 mL) and stirred overnight at room temperature. The reaction mixture is partitioned between water and ether. The organic layer is washed with water, dried, and concentrated. The residue is purified by silica gel chromatography, eluting with 15-20% EtOAc in hexanes, to afford the title compound.

来源