反应 #4208

反应方程式

chloroacetyl chloride

potassium bicarbonate

3,4-dibenzyloxyaniline

chloroacetyl chloride

→

2-Chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

溶剂

acetonitrile water

反应条件

后处理

1. 1
   温度while maintaining the pH at 6.5
2. 2
   workup.WAITWhen the pH remained constant for 15 minutes
3. 3
   其他the acetonitrile was evaporated
4. 4
   过滤the resulting aqueous solution was filtered
5. 5
   洗涤The precipitate was washed thoroughly with water
6. 6
   其他to yield
7. 7
   干燥upon drying in vacuo, 8.98 g of the title compound

实验过程

To 7.7 g (25 mmol) of 3,4-dibenzyloxyaniline in 50 ml of 1:1 acetonitrile/water at 0° C. was added chloroacetyl chloride (3.0 ml) while keeping the pH at 6.5 with saturated aqueous potassium bicarbonate. When the pH remained constant for 15 minutes, an additional 3 ml of chloroacetyl chloride was added in small portions while maintaining the pH at 6.5. When the pH remained constant for 15 minutes, the acetonitrile was evaporated, and the resulting aqueous solution was filtered. The precipitate was washed thoroughly with water to yield, upon drying in vacuo, 8.98 g of the title compound.

来源