反应 #41998

反应方程式

N-{3-[5-fluoro-1-(3-iodo-propyl)-indan-1-yl]-1H-indol-7-yl}-methane sulfonamide

morpholine

→

title compound

收率 83.0%

N-{3-[5-Fluoro-1-(3-morpholin-4-yl-propyl)-indan-1-yl]-1H-indol-7-yl}-methanesulfonamide

收率 83.0%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   其他Remove the volatiles under high vacuum
2. 2
   workup.DISSOLUTIONdissolve the residue in dichloromethane
3. 3
   workup.ADDITIONadd solid potassium carbonate
4. 4
   过滤filter
5. 5
   浓缩concentrate in vacuo
6. 6
   其他Purify the residue on silica eluting with 5 to 10% methanol in dichloromethane over 15 minutes

实验过程

Combine N-{3-[5-fluoro-1-(3-iodo-propyl)-indan-1-yl]-1H-indol-7-yl}-methane sulfonamide (65 mg, 0.13 mmol) and morpholine (2 ml) in anhydrous tetrahydrofuran (2.5 ml) and stir at room temperature under nitrogen overnight. Remove the volatiles under high vacuum, dissolve the residue in dichloromethane, add solid potassium carbonate, stir for ten minutes, filter, and concentrate in vacuo. Purify the residue on silica eluting with 5 to 10% methanol in dichloromethane over 15 minutes to obtain the title compound as a white solid (50 mg, 83%). LC-MS m/z 472.2 (M++1).

来源