反应 #41991

反应方程式

3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine

methyl chloroformate

→

title compound

收率 36.0%

[3-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indol-7-yl]-carbamic acid methyl ester

收率 36.0%

溶剂

ether

pyridine

反应条件

后处理

1. 1
   洗涤wash with 1N aqueous hydrochloric acid (2×)
2. 2
   干燥dry over anhydrous sodium sulfate
3. 3
   过滤filter
4. 4
   浓缩concentrate solution in vacuo
5. 5
   其他Purify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes

实验过程

Dissolve 3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indol-7-ylamine (0.35 g, 1.19 mmol) in pyridine (3 ml). Add methyl chloroformate (0.10 ml, 1.31 mmol, 1.1 equivalents) and stir at room temperature under nitrogen overnight. Dilute with ether, wash with 1N aqueous hydrochloric acid (2×), dry over anhydrous sodium sulfate, filter, and concentrate solution in vacuo. Purify the residue on silica eluting with 0 to 75% ethyl acetate/hexanes over 30 minutes to provide the title compound as a white solid (0.15 g, 36%). LC-MS m/z 353.1 (M++1).

来源