反应 #41965

反应方程式

triphenylphosphine

3-bromopropionic acid

ether

→

title compound

收率 68.5%

(2-Carboxy-ethyl)-triphenyl-phosphonium bromide

收率 68.5%

溶剂

acetonitrile

反应条件

后处理

1. 1
   过滤Filter solids
2. 2
   洗涤rinse with ether
3. 3
   其他dry solids under high vacuum

实验过程

Reflux a solution of triphenylphosphine (91.3 g, 348 mmol, 1.05 equivalents) and 3-bromopropionic acid (50.7 g, 331 mmol) in acetonitrile (250 ml) for three hours, allow to sit at room temperature overnight. Add ether (400 ml) and cool in the freezer for two hours. Filter solids, rinse with ether, and dry solids under high vacuum to obtain the title compound (94.1 g, 68%). NMR (400 MHz, CDCl3): δ 3.15 (m, 2H), 3.73 (m, 2H), 7.69-7.83 (m, 15H).

来源