反应 #41925

反应方程式

Trifluoroacetic acid

tert-butyl 2-(1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetate

→

2-(1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid

收率 29.0%

反应条件

后处理

1. 1
   其他Trifluoroacetic acid was removed under vacuum
2. 2
   洗涤the resulting solids were washed with water (3×), ether (3×)
3. 3
   其他dried in a vacuum oven at 50° C.

实验过程

Trifluoroacetic acid (1.00 ml, 13 mmol) was added to tert-butyl 2-(1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetate (0.021 g, 0.07 mmol) and stirred at room temperature for 15 minutes. Trifluoroacetic acid was removed under vacuum and the resulting solids were washed with water (3×), ether (3×) and dried in a vacuum oven at 50° C. to afford 2-(1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid in 29% yield.

来源