反应 #417992

反应方程式

4-iodophenol

1-bromo-2-methylpropane

K2CO3

→

1-Iodo-4-isobutoxybenzene

溶剂

DMF

water

反应条件

后处理

1. 1
   萃取extracted with EtOAc
2. 2
   洗涤The organic layer is washed with diluted aq. NaOH (2×) and water (2×)
3. 3
   干燥dried over MgSO4
4. 4
   其他the solvent is removed in vacuo
5. 5
   其他The crude product is used without further purification

实验过程

3.00 g (13.6 mmol) 4-iodophenol, 1.60 mL (15.0 mmol) 1-bromo-2-methylpropane and 7.50 g (54.5 mmol) K2CO3 are dissolved in 30 mL DMF and stirred at 80° C. for 4 h. Afterwards the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is washed with diluted aq. NaOH (2×) and water (2×), dried over MgSO4 and the solvent is removed in vacuo. The crude product is used without further purification.

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