反应 #417990

反应方程式

5-chloro-3-(3-nitrobenzyl)-3H-benzothiazol-2-one

→

3-(3-aminobenzyl)-5-chloro-3H-benzothiazol-2-one

溶剂

THF

反应条件

后处理

1. 1
   其他prepared analogously to “A12”
2. 2
   其他hydrogenated under a hydrogen atmosphere at room temperature
3. 3
   过滤the catalyst is filtered off with suction
4. 4
   洗涤rinsed with THF
5. 5
   其他evaporated

实验过程

4.5 g (12.8 mol) of 5-chloro-3-(3-nitrobenzyl)-3H-benzothiazol-2-one [“A13a”; prepared analogously to “A12”; ESI: 321 (M+H); Rt.=3.20 min (method A)] are dissolved in 100 ml of THF and hydrogenated under a hydrogen atmosphere at room temperature using 2 g of palladium on active carbon (water-moist, 5% of Pd). After 24 h, the catalyst is filtered off with suction, rinsed with THF and evaporated, giving 3-(3-aminobenzyl)-5-chloro-3H-benzothiazol-2-one, ESI: 291 (M+H); HPLC: Rt.=2.28 min (method A).

来源