反应 #417989

反应方程式

water

5-chloro-3H-benzothiazol-2-one

3-(3-bromomethylphenyl)-5-methyl-1,2,4-oxadiazole

potassium carbonate

→

5-chloro-3-[3-(5-methyl-1,2,4-oxadiazol-3-yl)benzyl]-3H-benzothiazol-2-one

溶剂

acetonitrile

反应条件

后处理

1. 1
   萃取is then extracted with MTBE
2. 2
   其他dried
3. 3
   其他evaporated to dryness
4. 4
   其他The crude product is purified by column chromatography on silica gel
5. 5
   workup.STIRRINGstirred with ether
6. 6
   其他giving “A12”
7. 7
   其他=3.25 min (method A)

实验过程

A suspension of 100 mg (0.54 mmol) of 5-chloro-3H-benzothiazol-2-one, 153 mg (0.59 mmol) of 3-(3-bromomethylphenyl)-5-methyl-1,2,4-oxadiazole and 303 mg (2.16 mmol) of potassium carbonate in 20 ml of acetonitrile are stirred at 80° C. for 1 h. 30 ml of water are added to the reaction mixture, which is then extracted with MTBE, dried and evaporated to dryness. The crude product is purified by column chromatography on silica gel and stirred with ether, giving “A12”: ESI: 358 (M+H); Rt.=3.25 min (method A);

来源