反应 #417987

反应方程式

water

5-trifluoromethyl-3H-benzothiazol-2-one

5-bromo-2-(3-chloromethylphenyl)pyrimidine

→

3-[3-(5-bromopyrimidin-2-yl)benzyl]-5-trifluoromethyl-3H-benzothiazol-2-one

溶剂

DMF

反应条件

后处理

1. 1
   过滤the precipitate is filtered off with suction
2. 2
   洗涤washed with methanol
3. 3
   其他dried in vacuo
4. 4
   其他giving beige crystals
5. 5
   其他=3.72 min (method A)

实验过程

1 g (4.56 mmol) of 5-trifluoromethyl-3H-benzothiazol-2-one, 1.3 g (4.56 mmol) of 5-bromo-2-(3-chloromethylphenyl)pyrimidine and 4.5 g (13.69 mmol) of caesium carbonates are suspended in 15 ml of DMF and stirred at room temperature for 15 h and at 80° C. for 3 h. The suspension is added to water, and the precipitate is filtered off with suction, washed with methanol and dried in vacuo, giving beige crystals; HPLC: Rt.=3.72 min (method A);

来源