反应 #417986

反应方程式

[3-(5-bromopyrimidin-2-yl)phenyl]methanol

thionyl chloride

→

5-bromo-2-(3-chloromethylphenyl)pyrimidine

溶剂

dichloromethane

反应条件

后处理

1. 1
   温度with cooling
2. 2
   workup.DISTILLATIONThe solvent is distilled off
3. 3
   workup.STIRRINGco-evaporated 3 times with toluene and stirred with diethyl ether

实验过程

80 g (302 mmol) of [3-(5-bromopyrimidin-2-yl)phenyl]methanol are suspended in 300 ml of dichloromethane, and 33 ml (453 mmol) of thionyl chloride are slowly added with cooling. The reaction mixture is stirred at room temperature for 3 h. The solvent is distilled off, co-evaporated 3 times with toluene and stirred with diethyl ether;

来源