反应 #417984

反应方程式

3-{3-[5-(1-tert-butoxycarbonylpiperidin-4-yl-methoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one

HCl

→

3-{3-[5-(piperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one

溶剂

dioxane

dioxane

反应条件

后处理

1. 1
   过滤A viscous precipitate forms in the process, which is filtered off with suction
2. 2
   workup.STIRRINGstirred with isopropanol

实验过程

424 mg (0.64 mmol) of 3-{3-[5-(1-tert-butoxycarbonylpiperidin-4-yl-methoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one is dissolved in 20 ml of dioxane, and 6 ml of 4N HCl in dioxane are added. The mixture is stirred at room temperature for 24 h. A viscous precipitate forms in the process, which is filtered off with suction and stirred with isopropanol.

来源