反应 #417982

反应方程式

water

5-trifluoromethyl-3H-benzothiazol-2-one

4-{2-[2-(3-chloromethylphenyl)pyrimidin-5-yl-oxy]ethyl}morpholine hydrochloride

potassium carbonate

→

3-{3-[5-(2-morpholin-4-ylethoxy)pyrimidin-2-yl]benzyl}-5-trifluoromethyl-3H-benzothiazol-2-one

溶剂

acetonitrile

反应条件

后处理

1. 1
   其他slowly forming
2. 2
   过滤The precipitate is filtered off with suction
3. 3
   洗涤washed with water
4. 4
   其他dried

实验过程

A suspension of 89 mg (0.405 mmol) of 5-trifluoromethyl-3H-benzothiazol-2-one, 150 mg (0.405 mmol) of 4-{2-[2-(3-chloromethylphenyl)pyrimidin-5-yl-oxy]ethyl}morpholine hydrochloride and 286 mg (2.02 mmol) of potassium carbonate in 8 ml of acetonitrile are stirred at 70° C. for 5 days. 30 ml of water are added to the reaction mixture, with a precipitate slowly forming. The precipitate is filtered off with suction, washed with water and dried.

来源