反应 #417976

反应方程式

sulfuric acid

3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoic acid

methanol

water

→

methyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate

反应条件

后处理

1. 1
   温度the mixture is heated at the boil for 18 hours
2. 2
   温度The reaction mixture is cooled in an ice bath
3. 3
   过滤the mixture is filtered off with suction
4. 4
   洗涤washed well with water
5. 5
   其他=2.65 min (method A)

实验过程

7.83 ml (147 mmol) of concentrated sulfuric acid are added to a suspension of 30.0 g (147 mmol) of 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoic acid in 150 ml of methanol, and the mixture is heated at the boil for 18 hours. The reaction mixture is cooled in an ice bath, water is added, the mixture is filtered off with suction and washed well with water: methyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate as colourless crystals; m.p. 81° C., ESI 219 (M+H), HPLC: Rt.=2.65 min (method A).

来源