反应 #417975

反应方程式

3-(N-hydroxycarbamimidoyl)benzoic acid

acetic anhydride

→

3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoic acid

溶剂

acetic acid

反应条件

后处理

1. 1
   温度The reaction mixture is cooled to 6° C.
2. 2
   过滤filtered off with suction
3. 3
   过滤filtered off with suction
4. 4
   洗涤washed well with water
5. 5
   其他The residue is recrystallised from ethanol/water

实验过程

A mixture of 614 g (3.41 mol) of 3-(N-hydroxycarbamimidoyl)benzoic acid, 756 ml (8.0 mol) of acetic anhydride and 2 l of acetic acid is heated at a temperature of 118° C. for 14 hours. The reaction mixture is cooled to 6° C. and filtered off with suction. The residue is taken up in 2 l of water, filtered off with suction and washed well with water. The residue is recrystallised from ethanol/water: 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoic acid as colourless crystals; m.p. 225°; ESI 205 (M+H).

来源