反应 #417972

反应方程式

Water

compound 26a

2-(3-bromo-propoxy)-1-chloro-4-nitro benzene

N-phenyl piperazine

potassium carbonate

→

title compound 26b

收率 78.0%

1-[3-(2-chloro-5-nitro-phenoxy)-propyl]-4-phenyl-piperazine

收率 78.0%

溶剂

DMF

反应条件

后处理

1. 1
   其他at room temperature
2. 2
   萃取extracted with ethyl acetate (3×20 mL)
3. 3
   干燥The combined extracts were dried over sodium sulfate
4. 4
   浓缩concentrated under reduced pressure
5. 5
   其他The crude product was purified by flash column chromatography

实验过程

To the compound 26a (2.1 g, 7.1 mmol) in DMF (9 mL) was added N-phenyl piperazine (1.16 g, 7.1 mmol) and potassium carbonate (1.28 g, 9.23 mmol). The mixture was stirred for 18 hrs. at room temperature. Water (10 mL) was added to the reaction mixture and extracted with ethyl acetate (3×20 mL). The combined extracts were dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by flash column chromatography to get the title compound 26b in 78% yield as yellow solid.

来源