反应 #417964

反应方程式

Acetic anhydride

4-chloro-3-hydroxy aniline

→

product 17a

收率 93.0%

N-(4-chloro-3-hydroxyphenyl)acetamide

收率 93.0%

溶剂

acetic acid

反应条件

后处理

1. 1
   温度the reaction was refluxed for 5 mins
2. 2
   过滤It was filtered off
3. 3
   洗涤washed with water (10 mL)
4. 4
   其他dried

实验过程

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

来源