反应 #417952

反应方程式

dimethyl sulfone

sodium-bis-(trimethylsilyl)-amide

THF

2-bromo-6-fluoropyridine

→

2-Bromo-6-(1-methanesulfonyl-cyclopropyl)-pyridine

反应条件

后处理

1. 1
   其他The reaction is quenched by the addition
2. 2
   萃取NaCl solution and extracted with EtOAc
3. 3
   干燥The organic layer is dried over MgSO4
4. 4
   过滤filtered
5. 5
   其他the solvent is removed in vacuo

实验过程

Under inert gas atmosphere 28.4 mL (56.8 mmol) of a sodium-bis-(trimethylsilyl)-amide solution in THF (c=2 mol/L) are chilled to −17° C. and dropwise charged with 2.00 g (11.3 mmol) 2-bromo-6-fluoropyridine. Afterwards 2.14 g (22.7 mmol) dimethyl sulfone are added and the reaction mixture is stirred at −17° C. for 1 h. The reaction is quenched by the addition of aq. sat.NaCl solution and extracted with EtOAc. The organic layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

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