反应 #417951

反应方程式

4-bromo-5-fluoro-pyridin-2-ol

ethyliodide

→

4-Bromo-2-ethoxy-5-fluoro-pyridine

溶剂

DCM

反应条件

后处理

1. 1
   其他The reaction is quenched by the addition of water
2. 2
   workup.ADDITIONDCM is added
3. 3
   过滤the resulting mixture is filtered
4. 4
   干燥dried over MgSO4
5. 5
   过滤filtered again
6. 6
   其他the solvent is removed in vacuo

实验过程

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo.

来源