反应 #417949

反应方程式

5-bromo-2-fluoropyridine

cyclopropane methanol

NaH

→

5-Bromo-2-cyclopropylmethoxy-pyridine

溶剂

THF

反应条件

后处理

1. 1
   workup.STIRRINGthe mixture is stirred at r.t. over night
2. 2
   其他The reaction is quenched by the addition of water
3. 3
   萃取extracted with EtOAc
4. 4
   干燥dried over MgSO4
5. 5
   过滤filtered
6. 6
   其他the solvent is removed in vacuo
7. 7
   其他The crude product is purified by HPLC (MeOH/H2O/FA)

实验过程

0.49 g (6.82 mmol) cyclopropane methanol in 10 mL THF are charged with 0.42 g (11.4 mmol) NaH and the reaction mixture is stirred at r.t. for 20 min. Then 1.00 g (5.68 mmol) 5-bromo-2-fluoropyridine are added and the mixture is stirred at r.t. over night. The reaction is quenched by the addition of water and extracted with EtOAc. The organic layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by HPLC (MeOH/H2O/FA).

来源