反应 #417948

反应方程式

2-bromo-5-hydroxypyridine

1-bromopropane

K2CO3

→

2-Bromo-5-propoxy-pyridine

溶剂

ACN

反应条件

后处理

1. 1
   温度at reflux over night
2. 2
   其他Afterwards the reaction is quenched by the addition of water
3. 3
   萃取extracted with TBME
4. 4
   干燥dried over MgSO4
5. 5
   过滤filtered
6. 6
   其他the solvent is removed in vacuo
7. 7
   其他The crude product is purified by column chromatography (silica gel, PE/EtOAc)

实验过程

10.0 g (57.5 mmol) 2-bromo-5-hydroxypyridine, 28.3 g (230 mmol) 1-bromopropane and 19.9 g (143.7 mmol) K2CO3 are added to 1 L ACN and stirred at reflux over night. Afterwards the reaction is quenched by the addition of water and extracted with TBME. The org. layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc).

来源