反应 #417946

反应方程式

2-bromo-2-fluoropyridine

(2,2-difluoro-ethyl)-methyl-amine hydrochloride

DIPEA

→

6-Bromo-N-(2,2-difluoroethyl)-N-methylpyridin-2-amine

反应条件

后处理

1. 1
   其他The reaction is quenched by the addition of water
2. 2
   萃取extracted with DCM
3. 3
   干燥layers are dried over MgSO4
4. 4
   过滤filtered

实验过程

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

来源