反应 #417943

反应方程式

(S)-1-(4-bromophenyl)ethylamine

acetic anhydride

→

(S)—N-(1-(4-Bromophenyl)ethyl)acetamide

溶剂

DCM

反应条件

后处理

1. 1
   其他Then the cooling is removed
2. 2
   洗涤Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
3. 3
   干燥layer is dried over MgSO4
4. 4
   过滤filtered
5. 5
   其他the solvent is removed in vacuo

实验过程

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

来源