反应 #41696

反应方程式

N-methoxy-N-methylamine hydrochloride

1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride

2-fluoro-4-nitrobenzoic acid

→

compound

2-fluoro-N-methoxy-N-methylbenzamide

溶剂

pyridine

反应条件

后处理

1. 1
   其他the reaction liquid
2. 2
   其他Pyridine was evaporated away under reduced pressure, and water
3. 3
   workup.ADDITIONwas added to it
4. 4
   过滤The resulting deposit was taken out through filtration
5. 5
   洗涤washed with water
6. 6
   其他dried

实验过程

5.79 g of N-methoxy-N-methylamine hydrochloride and 12.4 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (80 ml) suspension of 10 g of 2-fluoro-4-nitrobenzoic acid, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and water was added to it. The resulting deposit was taken out through filtration, washed with water, and dried to obtain the entitled compound as a pale yellow solid.

来源