反应 #416571

反应方程式

3-(2-thienyl)propionic acid

methylene chloride

→

3-(2-Thienyl)propionyl chloride

溶剂

oxalyl chloride

反应条件

后处理

1. 1
   浓缩was concentrated under vacuum and 20 ml of hexane
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   过滤The resulting mixture was filtered
4. 4
   浓缩the filtrate was concentrated under vacuum
5. 5
   其他The resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction

实验过程

To a solution of 5.0 g (0.032 mol) of 3-(2-thienyl)propionic acid in 2 ml of methylene chloride and 25 ml of oxalyl chloride was added three drops of N,N-dimethylformamide slowly. Following evolution of the gas the reaction mixture was concentrated under vacuum and 20 ml of hexane was added to the residue. The resulting mixture was filtered and the filtrate was concentrated under vacuum. The resulting compound, 3-(2-thienyl)propionyl chloride, was used directly in the following reaction.

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