反应 #41528

反应方程式

carbon disulfide

potassium hydroxide

ethanol

3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine

4-(4-Fluoro-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole

→

4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazole-2-thiol

溶剂

ethyl acetate

反应条件

后处理

1. 1
   其他the reaction liquid
2. 2
   其他The reaction liquid
3. 3
   洗涤washed with water and saturated saline in order
4. 4
   干燥dried with anhydrous magnesium sulfate
5. 5
   其他The solvent was evaporated away under reduced pressure
6. 6
   其他to obtain the entitled compound

实验过程

0.06 ml of carbon disulfide and 54 mg of potassium hydroxide were added to an ethanol (2.0 ml) solution of 273 mg of 3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 68, and the reaction liquid was stirred overnight at 80° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound.

来源