反应 #41456

反应方程式

HCl

4-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

收率 98.1%

溶剂

Water

DMF

反应条件

后处理

1. 1
   其他The light yellow precipitate that formed
2. 2
   过滤was collected by filtration
3. 3
   洗涤washed with water
4. 4
   其他dried in vacuo

实验过程

4-hydrazinylbenzoic acid (1.54 g, 10 mmol), 2-fluoro-5-iodobenzaldehyde (2.52 g, 10 mmol) and caesium carbonate (3.27 g, 10 mmol) was stirred in DMF (10 mL) at r.t. for 70 min. Water (40 mL) was then added and the clear solution was acidified with aqueous HCl (1.7 M). The light yellow precipitate that formed was collected by filtration, washed with water and dried in vacuo to give 4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (3.77 g, 98%)

来源