反应 #414194
ord-2be42446ab4248439eb14bf53a2ccb7e
反应方程式
反应物
试剂
反应条件
后处理
- 1workup.ADDITIONThe reaction temperature was kept between 20° C. and 27° C. during the addition
- 2其他The phases were separated
- 3干燥the organic phase dried with magnesium sulfate
- 4过滤filtered
- 5浓缩concentrated
- 6其他to yield 7.8 g of the crude product as a brown oil
- 7workup.STIRRINGAfter stirring for 10 minutes
- 8温度the reaction temperature was slowly increased to 90° C. for 2.5 hours
- 9温度to cool to room temperature
- 10workup.WAITstand overnight
- 11萃取the aqueous mixture was extracted with 200 ml of ethyl acetate
- 12其他the phases separated
- 13洗涤the organic phase washed with 100 ml of saturated sodium bicarbonate solution
- 14干燥dried with magnesium sulfate
- 15过滤filtered
- 16浓缩concentrated
- 17其他to yield the crude product as an oil
- 18其他flash chromatographed on Merck silica gel (230-400 mesh)
- 19浓缩concentrated
实验过程
A solution of 5.65 g of O-isopropyl P-ethyl(hydroxymethyl)phosphinate, (Example 22, Method B), 7.0 ml of triethylamine and 25 ml of methylene chloride was added dropwise over 45 minutes to a mixture of 50 ml of methylene chloride, 8.03 g of crude 2-methoxybenzenesulfonyl chloride, (Example 4), and 0.1 g of DMAP. The reaction temperature was kept between 20° C. and 27° C. during the addition. The reaction was allowed to stir at room temperature for four days and was then diluted with 80 ml of water and 100 ml of methylene chloride. The phases were separated, the organic phase dried with magnesium sulfate, filtered and concentrated to yield 7.8 g of the crude product as a brown oil. Phosphorus NMR indicated two products in a 1:1 ratio. The crude product was dissolved in 35 ml of acetic acid and 12 ml of 30% hydrogen peroxide solution was added. After stirring for 10 minutes, the reaction temperature was slowly increased to 90° C. for 2.5 hours. The reaction was allowed to cool to room temperature and stand overnight and was then poured onto 100 g of ice and the mixture diluted with 100 ml of water. After the ice had melted, the aqueous mixture was extracted with 200 ml of ethyl acetate, the phases separated, the organic phase washed with 100 ml of saturated sodium bicarbonate solution, dried with magnesium sulfate, filtered, and concentrated to yield the crude product as an oil. The oil was dissolved in 4 ml of methylene chloride and flash chromatographed on Merck silica gel (230-400 mesh) using blends of hexanes and ethyl acetate ranging from 30/70 to 10/90 hexanes and ethyl acetate, respectively. Similar fractions were combined and concentrated to yield 0.5 g of the desired product.