反应 #41379

反应方程式

(1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-amine

triethyl amine

2-chloro-2-oxoethyl acetate

→

N-((1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-yl)-2-hydroxyacetamide

溶剂

THF

反应条件

后处理

1. 1
   其他The solvent was removed under reduced pressure
2. 2
   workup.ADDITIONTo the crude solid was added Methanol (300 μl) and ammonium hydroxide (100 μl, 28%)
3. 3
   workup.STIRRINGThe solution was stirred over night

实验过程

To a stirred solution of (1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-amine (91a, 13 mg, 0.03 mmol) in dry THF (1 ml) were added, at r.t., triethyl amine (28 μl, 0.2 mmol) and 2-chloro-2-oxoethyl acetate (10.8 μl, 0.1 mmol). The reaction was stirred over night. The solvent was removed under reduced pressure. To the crude solid was added Methanol (300 μl) and ammonium hydroxide (100 μl, 28%). The solution was stirred over night.

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