反应 #413685

ord-ea8efaf98ee54e369bcb1938118bc370

反应方程式

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CI
21-iodo-16α-methylpregna-1,4,9(11)-triene-3,20-dione
c1ccc(-c2nc(-c3ccccn3)nc(N3CCNCC3)n2)nc1
4-[4,6-bis(2-pyridinyl)-1,3,5-triazin-2-yl]piperazine
→
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2nc(-c3ccccn3)nc(-c3ccccn3)n2)CC1
title compound
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2nc(-c3ccccn3)nc(-c3ccccn3)n2)CC1
16α-Methyl-21-[4-[4,6-bis(2-pyridinyl)-1,3,5-triazin-2-yl]-1-piperazinyl]pregna-1,4,9(11)-triene-3,20-dione

反应物

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CI
21-iodo-16α-methylpregna-1,4,9(11)-triene-3,20-dione
c1ccc(-c2nc(-c3ccccn3)nc(N3CCNCC3)n2)nc1
4-[4,6-bis(2-pyridinyl)-1,3,5-triazin-2-yl]piperazine

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

Following the general procedure of EXAMPLES 1-6A, 7, 8, 11-19, 83 and 126, and making non-critical variations but starting with 21-iodo-16α-methylpregna-1,4,9(11)-triene-3,20-dione (PREPARATION S-22) and 4-[4,6-bis(2-pyridinyl)-1,3,5-triazin-2-yl]piperazine (PREPARATION A-49) the title compound is obtained.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05268477uspto-grants-1993_12