反应 #413676

反应方程式

17α-Hydroxy-21-iodopregna-4,9(11)-diene-3,20-dione

1-(2-pyridinyl)piperazine

potassium carbonate

→

title compound

17α-Hydroxy-21-[4-(2-pyridinyl)-1-piperazinyl]pregna-4,9(11)-diene-3,20-dione

溶剂

acetonitrile

反应条件

后处理

1. 1
   其他The reaction is partitioned between ether and aqueous sodium bicarbonate
2. 2
   洗涤The organic phase is washed with saline
3. 3
   干燥dried over sodium sulfate
4. 4
   浓缩concentrated
5. 5
   其他The residue is chromatographed on silica gel with methanol/methylene chloride (4/96)

实验过程

17α-Hydroxy-21-iodopregna-4,9(11)-diene-3,20-dione (4.53 g) is stirred in acetonitrile (50 ml) with 1-(2-pyridinyl)piperazine (1.63 g) and potassium carbonate (1.34 g) at 60° for 5 hr and at 20°-25° for 17 hr. The reaction is partitioned between ether and aqueous sodium bicarbonate. The organic phase is washed with saline, dried over sodium sulfate and concentrated. The residue is chromatographed on silica gel with methanol/methylene chloride (4/96) to give the title compound.

来源