反应 #41317

ord-6b5f3b0c84704a3080fa24c3f84c6430

反应方程式

C[C@@H](N)[C@@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccccc1
(1S,2R)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-amine
COC(=O)C(=O)Cl
methyl cloro(oxo)acetate
COC(=O)C(=O)N[C@@H](C)[C@H](Oc1ccc2c(cnn2-c2ccc(F)cc2)c1)c1ccccc1
Methyl[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]carbamoylformate

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他Prepared

实验过程

Prepared as described in Example 1 using (1S,2R)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-phenylpropan-2-amine (1a, 18 mg, 50 μmol) and methyl cloro(oxo)acetate (18 mg, 150 μmol). Yield 18 mg (82%).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07728030B2uspto-grants-2010_06