反应 #41218

反应方程式

dichloromethane

4,5-Dihydroxy-9,10-dioxoanthracene-2-carboxylic acid

Benzyloxyacetyl chloride

water

ethyl acetate

→

4,5-Bis(2-benzyloxyacetyloxy)-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid

溶剂

pyridine

反应条件

后处理

1. 1
   其他to give a clear reaction mixture which
2. 2
   workup.STIRRINGwas stirred at RT over the weekend
3. 3
   其他quenched with 2M HCl (200 ml)
4. 4
   其他An orange solid was isolated by filtration
5. 5
   其他A yellow solid was isolated by filtration (3.6 g, 61%)

实验过程

4,5-Dihydroxy-9,10-dioxoanthracene-2-carboxylic acid (3.0 g) was suspended in pyridine (100 ml) and stirred at RT for 30 mins. Benzyloxyacetyl chloride (3.6 g, 5 equiv.) was added, to give a clear reaction mixture which was stirred at RT over the weekend. The reaction mixture was reduced to a smaller volume and quenched with 2M HCl (200 ml), adjusting the pH to pH 2. An orange solid was isolated by filtration. This crude solid was slurried in water (30 ml), followed by ethyl acetate (30 ml) and dichloromethane (30 ml). A yellow solid was isolated by filtration (3.6 g, 61%).

来源