反应 #41207

反应方程式

4-piperazin-1-yl-phenol

methyl 3-bromo-butyrate

triethylamine

→

title compound

收率 59.3%

3-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-butyric acid methyl ester

收率 59.3%

溶剂

DMF

反应条件

后处理

1. 1
   workup.ADDITIONThe mixture was poured onto water
2. 2
   萃取extracted with ethyl acetate (50 ml×3)
3. 3
   洗涤The combined organic layers were washed with brine
4. 4
   干燥dried over anhydrous Na2SO4
5. 5
   其他evaporated under vacuum to dryness
6. 6
   其他The residue was purified by silica gel flash chromatography (1% methanol in CH2Cl2)

实验过程

To a mixture of 4-piperazin-1-yl-phenol (2 g, 11.2 mmol) and methyl 3-bromo-butyrate (2.03 g, 11.2 mmol) in DMF (5 mL) was added triethylamine (4.5 mL, 11.53 mmol) dropwise and the reaction mixture was stirred at ambient temperature overnight. The mixture was poured onto water and extracted with ethyl acetate (50 ml×3). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and evaporated under vacuum to dryness. The residue was purified by silica gel flash chromatography (1% methanol in CH2Cl2) to furnish the title compound (1.85 g, 59.3%); MS; m/z 279 (M+H).

来源