反应 #4112

反应方程式

9-bromo-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepin-6-one

4-methylpiperidine

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product

收率 83.0%

9-Bromo-6-(4-methyl-1-piperidinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

收率 83.0%

溶剂

toluene

反应条件

后处理

1. 1
   温度was heated under nitrogen
2. 2
   其他resulted
3. 3
   温度The mixture was refluxed for 3 hours
4. 4
   过滤filtered
5. 5
   workup.STIRRINGThe filtrate was stirred with 500 ml of 2N sodium hydroxide solution for 15 minutes
6. 6
   其他the layers were separated
7. 7
   萃取The aqueous phase was extracted with 250 ml of toluene
8. 8
   洗涤washed once with 2N sodium hydroxide solution, twice with water
9. 9
   干燥dried over anhydrous sodium sulfate
10. 10
    过滤filtered
11. 11
    浓缩concentrated in vacuo to an oil which
12. 12
    其他The solid was triturated twice with hexane

实验过程

A mixture of 4.73 g (0.0150 mole) of 9-bromo-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepin-6-one and 1000 ml of toluene was heated under nitrogen, with stirring, until a solution resulted. Then there was added 14.9 g (0.150 mole) of 4-methylpiperidine, followed by 8.54 g (0.045 mole) of titanium tetrachloride. The mixture was refluxed for 3 hours, cooled to room temperature and filtered. The filtrate was stirred with 500 ml of 2N sodium hydroxide solution for 15 minutes and the layers were separated. The aqueous phase was extracted with 250 ml of toluene. The toluene layers were combined, washed once with 2N sodium hydroxide solution, twice with water, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo to an oil which solidified. The solid was triturated twice with hexane to afford 4.9 g (83%) of product. Recrystallization from ethyl acetate provided the analytical sample, mp 177°-179° C.

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