反应 #41037

ord-2336106645ec442db20a116bc5a04bda

反应方程式

O=c1[nH]c(=O)n(CCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)cc1C(F)(F)F
5-(trifluoromethyl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2,4(1H,3H)-pyrimidinedione
Cl
HCl
→
Cl.O=c1[nH]c(=O)n(CCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)cc1C(F)(F)F
title compound
Cl.O=c1[nH]c(=O)n(CCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)cc1C(F)(F)F
5-(trifluoromethyl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2,4(1H,3H)-pyrimidinedione hydrochloride

反应物

O=c1[nH]c(=O)n(CCCCN2C[C@@H]3C[C@]3(c3ccc(C(F)(F)F)cc3)C2)cc1C(F)(F)F
5-(trifluoromethyl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2,4(1H,3H)-pyrimidinedione
Cl
HCl

试剂

无

溶剂

C1COCCO1
dioxane

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

5-(trifluoromethyl)-1-(4-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}butyl)-2,4(1H,3H)-pyrimidinedione was treated with a solution of 4N HCl in dioxane (200 μl) to give the title compound as a yellow solid.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07727988B2uspto-grants-2010_06