反应 #40894

反应方程式

7-bromoindole

dichloromethane

aluminum chloride

succinic acid monoethyl ester chloride

→

titled compound

ethyl 4-(7-bromo-1H-indol-3-yl)-4-oxobutanoate

溶剂

ethyl acetate

反应条件

后处理

1. 1
   workup.STIRRINGby stirring at room temperature for 5 hours
2. 2
   萃取followed by extraction with ethyl acetate
3. 3
   洗涤The organic layer was washed in turn with water and saturated saline
4. 4
   干燥dried over anhydrous sodium sulfate
5. 5
   浓缩concentrated
6. 6
   洗涤The residue was washed with diisopropyl ether

实验过程

To a dichloromethane (50 mL) solution of aluminum chloride (6.80 g), succinic acid monoethyl ester chloride (8.39 g) was added under ice cooling and the mixture was stirred for 30 minutes. To the mixture, 7-bromoindole (5.0 g) was added, followed by stirring at room temperature for 5 hours. To the reaction mixture, ice water and ethyl acetate were added, followed by extraction with ethyl acetate. The organic layer was washed in turn with water and saturated saline, dried over anhydrous sodium sulfate and then concentrated. The residue was washed with diisopropyl ether to obtain the titled compound having the following physical properties (6.04 g).

来源