反应 #40850

反应方程式

2-chloro-4,5-diphenyl-pyrimidine

2-Chloro-4,5-diphenyl-pyrimidine

sodium acetate

MeOH

→

title compound

Methyl 4,5-Diphenyl-pyrimidine-2-carboxylate

溶剂

THF

反应条件

后处理

1. 1
   其他CO (g) was bubbled through the solution
2. 2
   其他The solvent was removed in vacuo
3. 3
   其他the crude product was purified by column chromatography (10% ethyl acetate in hexane)

实验过程

A solution of 2-chloro-4,5-diphenyl-pyrimidine (107, 203 mg, 0.76 mmol) and sodium acetate (188 mg, 2.21 mmol) in MeOH (6 ml) and THF (2 ml) was degassed under argon for 10 min. Pd(OAc)2 (2.1 mg) and DPPF (13 mg) were added and CO (g) was bubbled through the solution. The reaction was heated to 110° C. in a sealed tube for 2 days. The solvent was removed in vacuo and the crude product was purified by column chromatography (10% ethyl acetate in hexane) to get the title compound.

来源