反应 #4071

反应方程式

methyl α-(2-methylphenyl)-β-methoxyacrylate

N-bromosuccinimide

succinimide

→

colorless crystals

收率 97.3%

Methyl α-(2-bromomethylphenyl)-β-methoxyacrylate

收率 97.3%

溶剂

CCl4

反应条件

后处理

1. 1
   过滤The mixture is filtered
2. 2
   其他the filtrate is evaporated down
3. 3
   workup.DISSOLUTIONthe oil which remains is dissolved in about 5 ml of acetone
4. 4
   其他brought to crystallization with n-hexane

实验过程

20.6 g of the methyl α-(2-methylphenyl)-β-methoxyacrylate obtained as described in method A, 17.65 g of N-bromosuccinimide, 0.2 g of azobisisobutyronitrile and 150 ml of CCl4 are slowly heated to 90° C. and kept at this temperature until all of the succinimide floats on the solvent. The mixture is filtered, the filtrate is evaporated down, and the oil which remains is dissolved in about 5 ml of acetone and brought to crystallization with n-hexane. 27.5 g of colorless crystals of melting point 86°-87° C. are obtained.

来源