反应 #40573

反应方程式

5-bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde

p-toluenesulfonylmethyl isocyanide

→

5-[5-Bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)-phenyl]oxazole

溶剂

methanol

反应条件

后处理

1. 1
   温度the reaction mixture is heated
2. 2
   温度to reflux for 18 h
3. 3
   workup.DISTILLATIONThe solvent is then distilled off
4. 4
   其他the crude product is purified by silica gel chromatography (ethyl acetate/heptane)

实验过程

1 g of 5-bromo-3-methoxy-2-(2-trimethylsilanylethoxymethoxy)benzaldehyde and 0.54 g of p-toluenesulfonylmethyl isocyanide are dissolved in 40 ml of methanol, 0.38 g of o-potassiumcarbonate is added in portions, and the reaction mixture is heated to reflux for 18 h. The solvent is then distilled off, and the crude product is purified by silica gel chromatography (ethyl acetate/heptane).

来源