反应 #40381

反应方程式

acetone

2,4-difluorobenzylmagnesium bromide

ammonium chloride

→

alcohol

1-(2,4-difluorophenyl)-2-methylpropan-2-ol

溶剂

diethyl ether

diethyl ether

反应条件

后处理

1. 1
   温度Then the mixture is refluxed for 1.5 hours
2. 2
   其他The ether phase is separated off
3. 3
   洗涤washed with water
4. 4
   干燥dried with sodium sulfate
5. 5
   其他evaporated down
6. 6
   workup.DISTILLATIONThe fractional distillation of the residue

实验过程

11.0 mL acetone, diluted with 50 mL diethyl ether, is added dropwise to a solution of 500 mL of 0.25 molar 2,4-difluorobenzylmagnesium bromide in diethyl ether within 20 minutes. Then the mixture is refluxed for 1.5 hours and then hydrolyzed with 10% ammonium chloride solution. The ether phase is separated off, washed with water, dried with sodium sulfate, and evaporated down. The fractional distillation of the residue yields the alcohol as a colorless liquid (boiling point: 70° C.-73° C./2 mmbar). Yield: 20.0 g (86%).

来源