反应 #40380

ord-f053f0ee2a084b4fb3d6510862a29e13

反应方程式

CCOC(O)C(=O)c1cccc2c1OC(OCc1ccccc1)C(=O)N2
benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one
Cc1cc(F)ccc1CC(C)(C)N
2-(4-fluoro-2-methylphenyl)-1,1-dimethylethylamine
Cl
hydrochloride
Cc1cc(F)ccc1CC(C)(C)NCC(O)c1cc(OCc2ccccc2)cc2c1OCC(=O)N2
6-benzyloxy-8-{2-[2-[4-fluoro-2-methylphenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-4H-benzo[1,4]oxazin-3-one

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

Prepared analogously to the method for Example 8(d) from 0.95 g (2.66 mmol) of benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one and 0.43 g (2.37 mmol) of 2-(4-fluoro-2-methylphenyl)-1,1-dimethylethylamine. Yield: 0.75 g (55%, hydrochloride); melting point 233° C.-236° C.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07727984B2uspto-grants-2010_06