反应 #40379

ord-2f2ca50b285c466c8332057972630786

反应方程式

Cc1cc(F)ccc1CC(C)(C)NC=O
N-[2-(4-fluoro-2-methylphenyl)-1,1-dimethylethyl]formamide
Cl
hydrochloride
Cc1cc(F)ccc1CC(C)(C)N
2-(4-fluoro-2-methylphenyl)-1,1-dimethylethylamine

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他is reacted

实验过程

In order to prepare the amine, 27.0 g (130 mmol) of N-[2-(4-fluoro-2-methylphenyl)-1,1-dimethylethyl]formamide is reacted as described in the method for Example 10(c). White solid. Yield: 15.5 g (55%, hydrochloride); melting point: 277° C.-280° C.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07727984B2uspto-grants-2010_06