反应 #40377

反应方程式

sodium hydroxide

sulfuric acid

sodium cyanide

1-fluoro-2-methyl-4-(2-methylpropenyl)benzene

→

N-[2-(4-fluoro-3-methylphenyl)-1,1-dimethylethyl]formamide

溶剂

acetic acid

acetic acid

—

ice water

反应条件

后处理

1. 1
   萃取extracted with dichloromethane
2. 2
   干燥The organic phase is dried with sodium sulfate
3. 3
   其他The slightly yellow oil thus obtained
4. 4
   其他is further reacted directly

实验过程

4.9 mL concentrated sulfuric acid are added dropwise at 5° C.-15° C. to 1.5 g (31 mmol) sodium cyanide in 5 mL glacial acetic acid. Then the mixture is combined with 3.9 g (24 mmol) of 1-fluoro-2-methyl-4-(2-methylpropenyl)benzene, dissolved in 10 mL glacial acetic acid, and stirred for 1 hour at 50° C.-60° C. The reaction mixture is diluted with ice water, made alkaline with concentrated sodium hydroxide solution, and extracted with dichloromethane. The organic phase is dried with sodium sulfate and freed from solvents in vacuo. The slightly yellow oil thus obtained is further reacted directly. Yield: 4.3 g (87%).

来源