反应 #40376

ord-a2344d268bf746db834448ce1d1b93c9

反应方程式

CCOC(O)C(=O)c1cc(OCc2ccccc2)cc2c1OCC(=O)N2
6-benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one
CCc1ccc(CC(C)(C)N)cc1
2-(4-ethylphenyl)-1,1-dimethylethylamine
Cl
hydrochloride
CCc1ccc(CC(C)(C)NCC(O)c2cc(OCc3ccccc3)cc3c2OCC(=O)N3)cc1
6-benzyloxy-8-{2-[2-(4-ethylphenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-4H-benzo [1,4]oxazin-3-one

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

The target compound is prepared analogously to the method for Example 8(d) from 2.14 g (6.0 mmol) of 6-benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one and 1.0 g (5.6 mmol) of 2-(4-ethylphenyl)-1,1-dimethylethylamine. White solid. Yield: 1.7 g (54%, hydrochloride); melting point 210° C.-214° C.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07727984B2uspto-grants-2010_06