反应 #40375

反应方程式

N-[2-(4-ethylphenyl)-1,1-dimethylethyl]acetamide

potassium hydroxide

hydrochloric acid

diethyl ether

→

2-(4-ethylphenyl)-1,1-dimethylethylamine

溶剂

acetonitrile

ethylene glycol

反应条件

后处理

1. 1
   萃取extracted three times with diethyl ether
2. 2
   洗涤The combined organic phases are washed with water
3. 3
   干燥dried with sodium sulfate
4. 4
   其他To prepare the hydrochloride
5. 5
   其他The solid precipitated
6. 6
   过滤filtered
7. 7
   其他dried

实验过程

16.3 g (74 mmol) of N-[2-(4-ethylphenyl)-1,1-dimethylethyl]acetamide and 8.0 g of potassium hydroxide are refluxed for 15 hours in 60 mL ethylene glycol. The reaction mixture is combined with ice water and extracted three times with diethyl ether. The combined organic phases are washed with water, dried with sodium sulfate, and freed from solvent. To prepare the hydrochloride, the crude product is dissolved in acetonitrile and ethereal hydrochloric acid and diethyl ether are added successively. The solid precipitated is suction filtered and dried. Yield: 11.0 g (69%, hydrochloride); melting point 165° C.-167° C.

来源