反应 #40373

反应方程式

ammonium chloride

methylmagnesium bromide

1-(4-ethylphenyl)propan-2-one

→

1-(4-ethylphenyl)-2-methylpropan-2-ol

溶剂

diethyl ether

diethyl ether

反应条件

后处理

1. 1
   温度while being cooled with an ice bath in such a way that the temperature
2. 2
   其他does not exceed 30° C
3. 3
   workup.ADDITIONAfter the addition
4. 4
   温度the reaction mixture is refluxed for 1.5 hours
5. 5
   其他After the removal of the organic phase
6. 6
   萃取the aqueous phase is extracted with diethyl ether
7. 7
   洗涤The combined ether phases are washed with water
8. 8
   干燥dried with sodium sulfate
9. 9
   其他evaporated down
10. 10
    其他The oil thus obtained
11. 11
    其他is further reacted directly

实验过程

14.8 g (90 mmol) of 1-(4-ethylphenyl)propan-2-one dissolved in diethyl ether is added dropwise to 39 mL of a 3 molar solution of methylmagnesium bromide in diethyl ether while being cooled with an ice bath in such a way that the temperature does not exceed 30° C. After the addition has ended, the reaction mixture is refluxed for 1.5 hours and then hydrolyzed with 10% ammonium chloride solution. After the removal of the organic phase, the aqueous phase is extracted with diethyl ether. The combined ether phases are washed with water, dried with sodium sulfate, and evaporated down. The oil thus obtained is further reacted directly. Yield: 15.5 g (90%).

来源