反应 #40340

反应方程式

caustic soda

1-bromohexane

N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine

caesium carbonate

→

title compound

N-(5-hexyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine

溶剂

dimethylformamide

反应条件

后处理

1. 1
   萃取is extracted with ethyl acetate
2. 2
   干燥the combined organic phases are dried over sodium sulphate
3. 3
   浓缩concentrated by evaporation

实验过程

1-bromohexane (0.11 mmol) is added to a suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine (0.1 mmol) and caesium carbonate (0.22 mmol) in dimethylformamide (0.3 ml) and the reaction mixture is stirred overnight at room temperature. After adding 2M caustic soda solution (1 ml) the mixture is extracted with ethyl acetate, the combined organic phases are dried over sodium sulphate and then concentrated by evaporation, the title compound being obtained in pure form.

来源