反应 #40330

反应方程式

8-(4-fluor-phenyl)-1,4-dioxaspiro[4.5]decane

sulphuric acid

→

raw title compound

4-(4-fluorophenyl)-cyclohexanone

溶剂

dioxane

反应条件

后处理

1. 1
   萃取After dilution with water (12 ml) extraction

实验过程

8-(4-fluor-phenyl)-1,4-dioxaspiro[4.5]decane (2 mmol) is dissolved in dioxane (6.5 ml) and treated with 3 ml 50% aqueous sulphuric acid accompanied by stirring at room temperature for 5 hours. After dilution with water (12 ml) extraction is carried out twice with dichloromethane. The raw title compound is obtained from the combined organic phases after drying over sodium sulphate and evaporating-off of the solvent in a vacuum (Tetrahedron 1998, 54, 15509-15524): tR 3.44 min (LC-1); ESI-MS(+): m/z 193.29 [M+H]+.

来源