反应 #40285

反应方程式

Water

N-Boc-β-alanine

3-tert-Butoxycarbonylamino-propionic Acid

propargyl amine

Diisopropyl-carbodiimide

→

N-Boc-β-alanine Propargyl Amide

溶剂

THF

反应条件

后处理

1. 1
   萃取the product was extracted into EtOAc (3×30 mL)
2. 2
   干燥The combined EtOAc was dried (Na2SO4)
3. 3
   其他evaporated
4. 4
   其他The crude product was purified by silica column chromatography
5. 5
   洗涤eluting with EtOAc

实验过程

N-Boc-β-alanine (1a) (1.05 g, 5.5 mmol) and propargyl amine (0.90 g, 16.5 mmol) were dissolved in THF (10 mL). Diisopropyl-carbodiimide (DIC, 695 g, 5.5 mmol) was added and the reaction mixture was stirred for 16 h at room temperature. Water was added (20 mL) and the product was extracted into EtOAc (3×30 mL). The combined EtOAc was dried (Na2SO4) and evaporated. The crude product was purified by silica column chromatography eluting with EtOAc:Heptane gradient (2:3)-(3:2.5) (v/v). Product yield 0.925 g, 74%.

来源